Containment Isolators for OEB 4–6 & HPAPI

Engineered containment systems for high-potency and toxic compound handling

Ravona’s containment isolators are designed for maximum operator and environmental protection during the handling of highly potent active pharmaceutical ingredients (HPAPIs) and hazardous materials. Built for use in OEB 4–6 applications, these isolators maintain strict negative-pressure control and include multi-stage filtration, integrated monitoring, and flexible automation options.

Key Features and Benefits

  • OEB 4–6 Containment
    Designed for safe handling of toxic materials down to nanogram levels with complete operator protection.

  • Negative Pressure Operation
    Maintains internal pressure below room level to prevent any release of hazardous substances.

  • HEPA / ULPA Filtration
    Multi-stage air filtration system ensures capture of fine particles and airborne contaminants.

  • Environmental Monitoring
    Real-time sensors track pressure, particle levels, and air quality with automated alarm triggers.

  • Glove Ports & Remote Handling
    Supports manual glove access and robotic integration for automated material handling.

  • Decontamination Compatibility
    Can be equipped with vaporized hydrogen peroxide (VHP) systems or integrated clean-in-place (CIP) processes.

  • SCADA and HMI Integration
    Control system with audit-ready data logging and centralized monitoring capabilities.

  • Custom Configuration
    Built to meet your specific requirements, from R&D setups to full-scale production isolators.

Technical Specifications

  • Containment Level: OEB 4–6, suitable for HPAPI and cytotoxic materials

  • Pressure Control: Negative-pressure operation with regulated air exchange

  • Filtration: HEPA H14 or ULPA multi-stage filters

  • Monitoring: Integrated sensors for pressure, particle count, and airflow

  • Construction: GMP-grade stainless steel with glove ports and automation-ready design

  • Decontamination: Optional VHP or CIP systems

  • Control System: Touchscreen HMI with SCADA integration and data logging

  • Power & Utilities: Configurable to site-specific utility standards

Applications

  • Handling of cytotoxic drugs and HPAPIs

  • Oncology drug manufacturing

  • High-containment biologics and vaccine production

  • R&D and pilot-scale labs

  • Quality control and material transfer operations

  • API weighing, sampling, and dispensing