Isolators

Isolators are fully sealed barrier systems that provide the highest level of contamination control for aseptic processing and high-containment applications in pharmaceutical, biotech, and life sciences manufacturing. Distributed in the United States by TurboFil, RAVONA isolators are engineered to create controlled environments that protect products and operators during critical procedures.

This page presents TurboFil’s isolator solutions, including both aseptic isolators for sterile processing and containment isolators for handling high-potency active pharmaceutical ingredients (HPAPIs) and hazardous materials. Each system is customizable for specific workflows, compliance standards, and facility requirements.

Isolator Systems

  • Containment Isolator

    Function:
    Negative-pressure isolator designed for secure containment of hazardous and highly potent compounds in pharmaceutical and research environments.

    Container:
    Supports powder and liquid processing of APIs, biologics, and lab materials requiring high-containment protection.

    Output:
    Designed for batch or continuous operations with real-time monitoring and safe material handling workflows.

    Material:
    Constructed from GMP-compliant stainless steel with sealed glove ports, filtered exhaust, and full decontamination compatibility.

  • Aseptic isolator

    Aseptic Isolator

    Function:
    Closed-barrier isolator system that provides a Grade A / ISO 5 sterile environment for aseptic processing, with integrated decontamination and glove integrity testing support.

    Container:
    Designed for use with vials, syringes, cartridges, and other sterile components in fill-finish, testing, or containment workflows.

    Output:
    Supports batch processing with rapid decontamination cycles and uninterrupted aseptic operation; cycle times vary by configuration and use case.

    Material:
    GMP-grade stainless steel construction with frameless glove ports, HMI interface, and cleanroom-compatible finishes.

What Are Isolators?

Isolators are sealed, controlled enclosure systems that isolate the internal process environment from the external room environment to maintain sterility or containment. Unlike barrier systems such as RABS, isolators achieve complete physical separation, enabling strict control over airflow, pressure, and particulate conditions.

RAVONA isolators are designed to support Grade A / ISO 5 environments for aseptic processing, or negative-pressure containment for high-potency compounds, helping manufacturers meet stringent regulatory and quality expectations.

Isolator FAQs

An isolator is a sealed barrier system that completely separates the internal process environment from the external room, enabling sterile or containment processing with controlled airflow, pressure, and particulate conditions.

Isolators may operate under positive pressure for aseptic processing or negative pressure for containment applications. Pressure mode is selected based on whether product protection or operator protection is the primary requirement.

Yes. Isolators can be integrated with automated filling, stoppering, and sealing equipment to create a fully contained processing line that supports sterile manufacturing and regulatory compliance.

Isolators are engineered to maintain environments such as ISO 5/Grade A, with validated decontamination cycles, environmental monitoring, and sealed barriers that support GMP, FDA, and ISO standards.

Key selection criteria include process type (aseptic vs containment), target environment class, throughput requirements, facility HVAC strategy, and integration needs. Early consultation with applications engineers helps match isolator capabilities to your requirements.

Talk to an Isolator Solutions Specialist